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Probiotics are great for helping Diarrhea.

Do you know that you have literally millions of friendly bacteria that live in your gut?

What’s more, they’re essential to maintain good digestive function. Unfortunately, when you
experience diarrhea this upsets the normal balance of these friendly bacteria, also known as
probiotics. They are helpful bacteria or sometimes even healthy yeasts, and these friendly
bacteria help overcome many kinds of diarrhea.

The best understanding that we have about how beneficial probiotics can be is seen in studies
of diarrhea in kids, especially infectious diarrhea that is caused by rotavirus. The studies
show that probiotics shorten the time of kids having diarrhea by 1/2 to 2 days. The most
effective strains are Lactobacilllus reuteri and Saccharomyces boulardii. Infact Saccharomyces
Boulardii is one of the strains found in our best seller for kids, Primal Defense.

Traveling internationally is another reason for coming down with a bout of diarrhea. Very often
it’s a matter of eating contaminated food or water, or merely being a new environment where the
bacteria are unfamiliar to your body. is a frequent problem for travelers. Taking probiotics
before you travel can lower your risk of getting diarrhea. We get very good results with Dr
Ohhira’as Original Probiotics formula.

Talking about Dr Ohhira’s prrobiotic, there is clinical research to show its effectivity
against C. difficile
, which is often acquired after a hospital stay. C difficile may lead to
severe and sometimes life-threatening diarrhea and colitis. So taking these probiotics may help
prevent C. difficile infection and even more importantly that it may control repeat infections.

Other studies show that Saccharomyces boulardii and Lactobacillus GG are alos effective. In one
large study, people who were suffering with recurrent diarrhea were given a probiotic or a pill
that was not a probiotic, ie a placebo. They found that only 9 out of 26 people in the group
taking probiotics had a further recurrence of the diarrhea while in the other group who were
taking the placebo, 22 out of 34 had recurrent diarrhea.

Another probiotic that has been in the news lately, is VSL#3. This is because it has been shown
to be very effective in reducing symptoms of Ulcerative Colitis. This is a very important
finding because the drugs that are usually prescribed have many side effects with adverse
effects on the immune system.  Now the Junior Packs are also available.

Another very important time to be supplementing with probiotics is when taking antibiotics.
Unfortunately, although antibiotics kill the bad bacteria that make you sick, they also kill
the good bacteria. This leads to a dsiruption of the normal balance of the gut flora in the
gut and that may cause diarrhea. In fact, diarrhea is known to be a common side effect in as
many as 10% – 30% of those who take antibiotics. We recommend that you consider giving your
kids and even taking them yourself, before, during and most importantly after you take

This will lower your risk or at least shorten the length of time you experience diarrhea.
Studies using Saccharomyces boulardii and Lactobacillus GG seem to be the most effective.
Lactobacillus GG is the probiotic used in Culturelle.

Probiotics are very safe to use for people of all ages. They rarely cause side effects, perhaps
some gas, however, that’s usually due to a type of  ‘detox’ or Herxheimer reaction when the bad
bacteria are dying off andcausing symptoms. Other important factors to take into account are
the quality and strength of the particular brand. Its very important to select effective
probiotics and also to take a high enough number of live microorganisms to make it worth while

A Powerful New Paradigm for GI health

 Dr. Ohhira’s Probiotics Professional Formula

5-year Fermentation Process
– Concentrated organic acid content promotes healthy pH faster
– Higher content of bacteriocins, enzymes, micronutrients, and amino acids to maintain mucosal integrity and epithelial cells*
-12 carefully selected strains of beneficial LIVE lactic acid bacteria (LAB), fermented together
– Uses proprietary TH10 LAB strain — proteolytic activity 6.25 times stronger than other known LAB.
– No refrigeration needed due to fermentation at ambient temperatures

Complete Biogenic Matrix
– Supports a balanced gut pH and maintains epithelial cells
– Proven to support gut integrity and mucosal membrane health
– Promotes growth of the individual’s own unique beneficial flora

Research-Backed Results
– Ideal for those with significant digestive health goals and people with immune health challenges
– Supports the body’s natural ability to pass fluids by promoting probiotic balance throughout the body
– Safe and effective for all ages

*1. Proteolytic activity of lactic acid bacteria contained in OMX (Dr. Ohhira’s Probiotics Professional Formula): Ohhira, Ph.D., lichiroh,; Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan.

Welcome to Your New Probiotic Paradigm
How does Dr. Ohhira measure probiotic efficacy? With over 20 years of research and products that deliver effective results.

Based on 20 years of university-based scientific research, Dr. Ohhira’s Probiotics Professional Formula provides a gut-health system unlike any other on the market. Twelve carefully selected strains of beneficial LIVE lactic acid bacteria are fermented together for five years. The probiotics are encapsulated along with their nourishing culture medium and biogenic products.

This is the difference in Dr. Ohhira’s products. Its whole food matrix nourishes both supplemented probiotics and the individual’s own inherent friendly bacteria. It also quickly and effectively promotes a healthy gut pH, which ensures the long-term health of the beneficial organisms and the person’s health, too!

Did you know?
The body relies on probiotics to:
– Create essential fatty acids and vitamins (A, B,, Bz, B3, B6, B12, K, and Biotin)
– Support overall digestion and create lactase for dairy digestion
– Support the body’s ability to detoxify itself
– Support hormonal balance
– Support healthy cholesterol and triglyceride levels 
– Promote normal ongoing cell repair
– Promote a balanced inflammatory response and healthy immune response



 How does the industry measure probiotic efficacy?

Myth: “Billions” is best
Fact: As in nature, diversity delivers sustainable results

If you had a significant research objective, you wouldn’t gather a group of warm bodies to complete your tasks. You would hand-pick individuals based on their experience and ability to work together, then trainthem for their specific responsibilities.

The same goes for probiotic organisms. When we send billions of a single strain of bacteria into the human gut, this monoculture is like an untrained workforce. For some people, the onslaught can even trigger an artificial immune response. For others, pre-existing flora wind up dominating the supplemented strain. In the end, the “billions and billions” are unqualified for their task and may literally go to waste.

Myth: Freeze-dried multi-strains deliver diverse probiotic support
Fact: Fermented LIVE multi-strains guarantee the needed flora diversity

If billions of one strain doesn’t work, maybe billions of several strains will do the trick, right? Unfortunately, no. Many multi-strain products have to be freeze-dried because the individual strains will actually cannibalize each other_ And that is precisely what can happen when the bacteria awaken in the gut.

It is vital to provide the gut with supplemental diversity though. The only way to do this effectively is to ferment multiple strains together in a fashion that allows the individual strains to thrive off their own food supplies and adopt to each other’s presence. It’s not just survival of the fittest, it’s survival of the most beneficial…..Natural Selection!
That’s the secret behind Dr. Ohhira’s Probiotics Professional Formula.

Myth: Prebiotics are nice but not necessary
Fact: Prebiotics are integral for supporting long-term gut and immune health

That’s why Dr. Ohhira‘s Probiotics Professional Formula is so effective, so fast. The capsules contain not only diverse probiotic populations, but also their nourishment and all the biogenic GI health nutrients that probiotics naturally produce.

It’s like sending the supplemented strains into the gut along with a bag lunch and all the tools they need to maintain the gut lining. It’s the prebiotic food supply and the biogenic components (organic acids, bacteriocins, enzymes, micronutrients, and amino acids) that ensure the probiotics’ survival and also support a balanced gut pH. The complete matrix promotes a friendly internal environment for the helpful flora. For years, this approach has been proven in studies to guarantee probiotic coherence.

Dr. Ohhira’s prebiotic and biogenic components are not simply a nice addition. They are the key to the Professional Formula’s incredible efficacy.

Probiotic Chocolate Now Available

There is a new kind of chocolate. This is chocolate with a difference. This is chocolate  full of probiotics.  It tastes like regular chocolate. Kids and adults don’t even know that they are eating chocolates filled with probiotics.

Probiotics..Hype or Help?

Image Courtesy:

Gastroenterologist Dr. Shek-Har Challa says he considers probiotics to be the new vitamin because the global market for probiotics is anticipated to reach more than $32 billion by the year 2014.

He says that 30 years ago we used to take vitamins only if we needed them. Now, we take vitamins because they help us with so many different conditions, and that’s where he thinks will happen as well with probiotics.

We know that there are literally trillions of strains of probiotics, and research shows the benefits of many go way beyond digestive health issues. For instance, Dr. Challa said that we know that probiotics decrease the incidence of colds, women’s health, decreased urinary tract infection, allergies, eczema, and weight loss.


Probiotics Boost Vitamin D

According to new research probiotic supplements help to boost Vitamin D levels.  Read all about it as well as our MONTHLY SPECIALS…

New research shows that probiotic supplements help to boost Vitamin D levels.

Dr Jones was the lead study author of a study published in the ‘Journal of Clinical Endocrinology & Metabolism‘.  He is also the chief scientific officer at the probiotic company Micropharma Limited. His team of researchers looked at the effects of the probiotics after a supplement had been taken by a group of adults for nine weeks.

The probiotic supplement boosted levels of the vitamin by more than 25 per cent. This is the first evidence that probiotics play a role in maintaining levels of Vitamin D, the bone-strengthening nutrient.

Lactobacillus reuteri NCIMB 30242, one strain of probiotics, has shown to help cholesterol reduction, but its effect on the absorption of fat-soluble vitamins like Vitamin D was not known.

They tested levels of Vitamin D by monitoring levels of 25-hydroxyvitamin D in the blood.

Dr Johns says, ‘Although it has long been known that the gastrointestinal tract plays an active role in the absorption of Vitamin D, these findings showing improved Vitamin D status in response to an orally delivered probiotic are a first, and will inform the development of new products that may be beneficial for people with low Vitamin D levels. This study is adding to the body of knowledge on the microbiome (the community of bacteria in the gut) command and its role in human health.’

We all know that Vitamin D levels are of increasing concern because the number of adults developing osteoporosis as well as the numbers of children developing rickets are on the rise.
Low levels of Vitamin D contributes to these conditions because calcium absorption is reduced and so the bones are weakened.

Its very important to make sure that the Vitamon D supplement you choose is readily absorbable and also,  is potent enough to make the difference.


Probiotics Help Acne in Children

The New York Times released information earlier last week from the “Journal of Pedriatrics” on the growing number of children from 7-12 with acne. In recent years the growing number of children with acne has led parents and doctors alike on the search for age appropriate treatment options.


Acne has long been associated with the changing hormones and body growth due to puberty, but in light of acne affecting a younger demographic, Probiotic Action suggests parents should look at other factors instead of blaming hormones.

courtesy of


“Dirt, oil, bacteria, diet, and changing body chemistry are the contributing factors to acne. Parents should understand that acne is in many ways like other infections or illnesses, when our immune systems are compromised by external factors and internal stressors, infection and various conditions can happen without visible cause”, says Probiotic Spokesman, Fernando Perez.


Perez also suggests that parents should take note of the increased amount of processed foods children eat, and monitor the overuse of antibiotics to treat illnesses. Recent new headlines have told countless stories of new antibiotic resistant superbugs causing illness, which many believe could have been prevented by probiotic treatments and dietary changes instead of antibiotic use.


Probiotic Action recommends eating antibiotic free meat, lowering processed sugar intake, and starting a probiotic regimen, to treat children’s acne without chemicals, and improve their overall health. Taking these steps may help reduce the likelihood of new bacterial infections, and the growth of P.acnes bacteria.





24 Acknowledgements

Acknowledgements for Probiotics Article

O. Karimi received support from the Foundation of Immunogenetics. A.S. Pefia’s research in inflammatory bowel disease for 2002-2003 was supported in part by funding from the Crohn’s and Colitis Foundation of America (CCFA).


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23 Future Perspectives

Future Perspectives in Probiotic Use

Lactobacilli derived from the endogenous flora of normal donors are being increasingly used as probiotics in functional foods and as vaccine carriers. However, a variety of studies carried out with distinct strains of lactobacilli have suggested heterogeneous and strain-specific effects (Table IV).

To dissect this heterogeneity at the immunological level, Ibnou-Zekri et al. (137) selected two strains of lactobacilli that displayed similar properties in vitro and studied their impact on mucosal and systemic B-cell responses in monoxenic mice. Germ-free mice were colonized with L. johnsonii (NCC 533) or L. paracasei (NCC 2461). Bacterial loads were monitored for 30 days in intestinal tissues, and mucosal and systemic B-cell responses were measured.

Although both Lactobacillus strains displayed similar growth, survival, and adherence properties in vitro, they colonized the intestinal lumen and translocated into mucosal lymphoid organs at different densities. L. johnsonii colonized the intestine very efficiently at high levels, whereas the number of L. paracasei decreased rapidly and it colonized at low levels. They determined whether this difference in colonization correlated with an induction of different types of immune responses, and observed that colonization with either strain induced similar germinal center formation and IgA bearing lymphocytes in the mucosa, suggesting that both strains may activate mucosal B-cell responses.

However, clear differences in the patterns of immunoglobulins were observed between the two strains in the mucosa and in the periphery. Therefore, despite similar in vitro probiotic properties, distinct Lactobacillus strains may colonize the gut differently and generate divergent immune responses.

In another study, Coakley et al. (138), assessed strains of Lactobacillus, Lactococcus, Pediococcus and Bifidobacterium for their ability to produce the health-promoting fatty acid conjugated linoleic acid from free linoleic acid. Strains of Lactobacillus, Lactococcus, Pediococcus and Bifidobacterium were grown in medium containing free linoleic acid. Growth of the bacteria in linoleic acid and conversion of the linoleic acid to conjugated linoleic acid was assessed.

Of the bacteria assessed, nine strains of Bifidobacterium produced the cg, t11 CLA isomer from free linoleic acid. The cg, t11 conjugated linoleic acid isomer was also produced by some strains, but at much lower concentrations. Thus, the production of conjugated linoleic acid by bifidobacteria showed considerable interspecies variation.

Bifidobacterium breve and B. dentium were the most efficient producers of conjugated linoleic acid among the range of strains tested, with B. breve converting up to 65% linoleic acid to cg, t11 conjugated linoleic acid when grown in 0.55 mg/ml linoleic acid. Strains also varied considerably with respect to their sensitivity to linoleic acid. The production of conjugated linoleic acid by probiotic bifidobacteria offers a possible mechanism for some health-enhancing properties of bifidobacteria and provides novel opportunities for the development of functional foods.

Finally, it has been demonstrated that the therapeutic dose of IL-10 may be reduced by localized delivery of a probiotic genetically engineered to secrete the cytokine. Intra-gastric administration of IL10-secreting Lactococcus lactis caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10 gene-deficient mice (139). This observation has also opened the way for the use of probiotics as live vaccine delivery vectors (140).

22 Irritable Bowel Syndrome

Probiotics in Irritable Bowel Syndrome – IBS

Irritable Bowel Syndrome is a widespread and multi-factorial functional disorder of the digestive tract (114). It affects 8-22% of the population with a higher prevalence in women. It accounts for 20-50% of referrals to gastroenterology clinics and is char­acterized by abdominal pain, excessive flatus, vari­able bowel habit and abdominal bloating for which there is no evidence of detectable organic disease. Suggested etiologies include gut motility and psy­chological disorders as well as psycho-physiological phenomena and colonic fermentation (115).

A large proportion of patients have periods characterized by sudden and unforeseeable changes in the two main symptoms, constipation and diarrhea, even within a few days (115). It is very likely that the syndrome represents different groups of patients with probably different pathogenesis. Irritable bowel syndrome may follow gastroenteritis and may be associated with an abnormal gut flora and with food intolerance (117). The fecal microflora in some of these patients has been shown to be abnormal with higher numbers of facultative organ­isms and low numbers of lactobacilli and bifidobacteria (115).

Bacteria are the major component of formed stools and are influenced by substrates ar­riving with the ileal affluent. Stool production is re­lated to quantitative and qualitative aspects of the colonic microflora and nearly 80% of the fecal dry weight consists of bacteria, 50% of which are viable.

Although there is no evidence of food allergy in irritable bowel syndrome, food intolerance has been identified and exclusion diets are beneficial to many of these patients. Food intolerance may be caused by an abnormal fermentation of food residues in the colon, as a result of disruption of the normal flora (115).

Some reports suggest that probiotics play a role in regulating the motility of the digestive tract (114). This may result in improvements in pain and flatulence in response to probiotic administration (115).

To assess whether preceding gastroenteritis or food intolerance were associated with colonic malfermentation, King et al. (117) conducted a cross­over controlled trial with a standard diet and an ex­clusion diet matched for macronutrients in six fe­male patients with irritable bowel syndrome and six female controls.

In this study fecal excretion of fat, nitrogen, starch, and nonstarch polysaccharide was measured during the last 72 hours of each diet. The total excretion of hydrogen and methane were col­lected over 24 hours in purpose-built 1.4 m3 whole body calorimeter. Breath hydrogen and methane excretion were measured for 3 hours after 20 g oral lactulose. The maximum rate of gas excretion was significantly greater in patients than in controls. The total gas production in patients was not greater than in controls, whereas hydrogen production was higher.

After lactulose, breath hydrogen was greater on the standard than on the exclusion diet. This means that colonic-gas production, particularly of hydrogen, is greater in patients with irritable bowel disease than in controls, and both symptoms and gas production are reduced by an exclusion diet. This reduction may be associated with alterations in the activity of hydrogen-consuming bacteria. It was therefore concluded that fermentation may be an important factor in the pathogenesis of this syndrome (117).

Spiller et al. (118) studied the intestinal perme­ability (Iactulose/mannitol ratio) and histological and immunological features in rectal biopsy specimens in 21 patients who had acute Campylobacter enteritis, 10 patients with postdysenteric irritable bowel syndrome and 12 asymptomatic controls. They found that the increased enteroendocrine cell counts, T lymphocytes, and gut permeability, which may survive for more than a year after Campylobacter enteritis, contribute to post-dysenteric irrita­ble bowel syndrome (118), thus offering a rationale to use probiotics for several months after the infectious episode.

VSL3 in patients with Irritable Bowel Syndrome

The effect of the probiotics was studied by Brigidi et al. (119) in a clinical trial in which 10 patients suffering from this syndrome were adminis­tered the VSL#3 probiotic preparation. The results indicated that the administration of VSL#3 im­proved the clinical picture and changed the com­position and biochemistry of fecal microbiota. The exact mechanisms of the positive effects are not known. The selection of patients may have had an important role in detecting the positive effects. Whether the induction of a significant increase in lactobacilli, bifidobacteria, and S. thermaphilus con­tributed to the regulation of the motility disorders or the increase in fecal B-galactosidase with a decrease in urease content indicate that a good response requires further study. The importance of this study is that it showed that the measurement of specific parameters and changes in the specific microflora was possible.

Kim et al. (120) investigated the effects of VSL#3 on gastrointestinal transit and symptoms of patients with Rome II-Irritable Bowel Syndrome with predominant diarrhea. Twenty-five patients with diarrhea-predominant Irritable Bowel Syndrome were randomly assigned to receive VSL3 powder (450 billion lyophilized bacteria/day) or matching placebo twice daily for 8 weeks after a 2-week run-in period.

Pre- and post-treatment gastro-intestinal transit measurements were performed in all patients. The patients recorded their bowel function and symptoms daily in a diary during the 10-week study, which was powered to detect a 50% change in the primary colonic transit endpoint. There were no significant differences in mean gastrointestinal transit measurements, bowel function scores or satisfactory global symptom relief between the two treatment groups, pre- or post-therapy.

The differences in abdominal bloating scores between treatments were borderline significant. Abdominal bloating was reduced with VSL3, but not with placebo. Furthermore, VSL#3 had no effects on individual symptoms such as abdominal pain, gas and urgency. VSL3 was well tolerated by all patients, and thus it seems to relieve the abdominal bloating in patients with diarrhea-predominant Irritable Bowel Syndrome (120).

21 Probiotics in Crohn’s Disease

Probiotics in Crohn’s Disease

The therapeutic role of probiotics in the prevention of postoperative recurrence of Crohn’s disease has been reported in some studies. Gampieri et al. (111) studied the effects of VSL3 in a randomized, investigator-blind trial. Forty patients with curative resection randomized within 1 week post surgery were divided into two groups of 20 patients. One group received mesalazine 4 g/day for 1 year and the other group received rifaximin 1.8 g/day for 3 months followed by VSL#3 6 g/day for 9 months. The endoscopic activity was assessed after 3 and 12 months. In the mesalazine group, eight patients had severe endoscopic recurrence after 3 months as well as after 12 months, whereas in the group with rifaximin and VSL3, two patients had a severe recurrence after 3 months and two patients after 12 months.

These results suggested the efficacy of the combination of a nonabsorbable antibiotic with a highly concentrated probiotic preparation in the prevention of severe endoscopic recurrence of Crohns disease after surgical resection.

In a pilot study Guandalini et al (112) investigated the possible effect of Lactobacillus GG in children with active Crohns disease. Four male patients with a median age of 14.5 years (range 10-18) were enrolled. In terms of clinical outcome, the patients showed significant improvement. In three patients receiving Lactobacillus GG, it was possible to taper the dose of steroids.

In a third published study using Lactobacillus GG this effect could not be confirmed. Forty-five patients were randomized to receive Lactobacillus GG 12 billion GFU/day (23 patients) or placebo (22 patients). A clinical remission after 52 weeks was seen in 15 of the 23 patients with Lactobacillus GG (83.3%) and in 17 of the 22 patients with placebo (89.4%).

Mild endoscopic activity was seen in nine of the 15 patients with remission in the Lactobacillus GG group (60%) and in six of the 17 patients with remission in the placebo group (35.3%). This study failed to show effectiveness in the postoperative prevention on Crohn’s disease (113). More studies are therefore necessary. The limited experience indicates that different probiotics have different capacity to prevent intestinal inflammation.